Research

Molecular recognition is at the heart of essentially all biological processes, and hence much of drug discovery. All cellular functions depend on intermolecular interactions among biomolecules such as proteins, DNAs, RNAs, Carbohydrates etc. Our interest is focused on studying the detailed understanding of the underlying physical processes in these interactions. By comparing and contrasting the structural and thermodynamic features in several cases, we hope to distill out the generalities that are essential for understanding the molecular basis of recognition. Further, we want to use this information to identify modulators of such interactions, which can be used as potential drug candidates. Our group enjoys interdisciplinary research with a view to solving broader fundamental scientific problems at the interface of chemistry, biology and physics. The key areas are-

1.  Protein-protein interaction and its modulation by small molecules

2.  DNA condensation and impact of DNA binding drugs

3.  Protein-carbohydrate interaction

Our lab uses a combination of various biophysical and microscopic techniques such as; high throughput label-free techniques;for e.g. isothermal titration calorimetry (ITC) and surface plasmon resonance (SPR) to obtain quantitative thermodynamic parameters; AFM, DLS, TEM etc to gain deeper understanding of complex formation. Additionally, we use various spectroscopic as well as computational docking tools to gain additional insights into biomolecular interactions.